- HOU Ning,
- NING Hong-zhen,
- GAO Shang.et al,
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Abstract
Abstract
ObjectiveTo observe effect of red clover isoflavones on liver function and inflammatory response of non-alcoholic fatty liver disease in rats. MethodsTwelve male SD rats were assigned randomly to normal control group fed with normal diet and 42 to model group with emulsion gavage and 18% sucrose solution.Two rats from normal control group and two from model group were randomly selected and killed 4 weeks after treatments and their liver biopsy was conducted.Then the rats in model group were divided into 4 groups(n=10)according to their body weight:non-alcoholic fatty liver disease(NAFLD)model group,high-,mediun-,and low-dose red clover isoflavones treatment groups(75,150,and 300 mg/kg).The experiment period lasted for 12 weeks.At the end of experiment,all rats were killed and their serum and liver tissue samples were collected;then the contents of aspartate aminotransferase(AST),alanine aminotransferase(ALT),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),and C-reactive protein(CRP)were detected. ResultsCompared to those of model group,the hepatic cell damage was palliated and liver function was improved in red clover isoflavones treatment groups.The expressions of serum ALT(65.63±13.00 U/L)and AST(145.88±34.28 U/L)decreased in treatment groups(P<0.05 for all)and the contents of TNF-α(43.24±4.14 ng/mL),IL-6(69.94±6.98 pg/mL),and CRP(3.06±0.36 mg/L)also decreased significantly in the group. ConclusionRed clover isoflavones has protective effect on liver function and could reduce inflammatory response of liver in rats with non-alcoholic fatty liver.
FAQs
ConclusionRed clover isoflavones has protective effect on liver function and could reduce inflammatory response of liver in rats with non-alcoholic fatty liver.
Is red clover bad for the liver? ›
Health care practitioners believe that red clover "purified" the blood by acting as a diuretic (helping the body get rid of excess fluid) and expectorant (helping clear lungs of mucous), improving circulation, and helping cleanse the liver.
Who should not take red clover? ›
Red clover might act like estrogen, which could affect hormone balances during pregnancy or breast-feeding. Don't use it. Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Red clover might act like estrogen.
What is the best supplement to reduce fatty liver? ›
Try an omega-3 supplement
Research suggests that taking an omega-3 supplement may reduce liver fat and improve cholesterol levels. Talk with your doctor about how much you should take and if they believe the supplement route is better than the food route for you.
What supplement can reverse liver damage? ›
Vitamin B. Studies have shown that B vitamins can benefit liver function in several ways, including reversing liver inflammation. Many B vitamins, including vitamin B12 and folic acid, can improve liver health in people with fatty liver disease.
Which is better, black cohosh or red clover? ›
Herbal remedies such as red clover contain plant hormones that can act in a similar way to oestrogen, while black cohosh is believed to balance oestrogen and progestogen levels. These may help with some menopause symptoms but this is not supported by scientific evidence.
What is the toxicity of red clover? ›
Clover toxicity is caused by ingestion of alsike clover (Trifolium hybridum) or red clover (Trifolium pratense), resulting in signs of photosensitivity and liver failure.
Can red clover cause weight gain? ›
Does red clover cause weight loss? Since isoflavones can influence estradiol levels, they could cause weight gain. However, a human study of 93 post-menopausal women did not report any weight gain while taking red clover5.
Does red clover affect the kidneys? ›
Its anti-inflammatory properties may help reduce inflammation in the kidneys which can improve overall kidney function. Additionally, red clover tea's high antioxidant content may also help protect the kidneys from oxidative damage caused by free radicals.
Can red clover cause high blood pressure? ›
Lowers blood pressure: Red clover has special benefits that include lowering inflammation across the body, especially in the cardiovascular system. According to numerous studies, red clover tea can greatly decrease the tension in the arteries and blood vessels, which helps lower blood pressure.
Egg yolks are high in cholesterol. If you eat a lot, it can cause incomplete digestion of fats, adversely affect the liver, and reduce liver function. People with cirrhosis should not eat egg yolks. However, there are now many studies that contradict this view.
What heals fatty liver fast? ›
According to the American Liver Foundation, there are no medical treatments – yet – for non-alcoholic fatty liver disease. So that means that eating a healthy diet and exercising regularly are the best ways to both prevent liver damage from starting or reverse liver disease once it's in the early stages.
What are the 5 liver super foods? ›
Top foods and drinks for liver health
- Coffee. A 2021 study analyzed data from 494,585 people in the United Kingdom to learn how different types of coffee might affect the risk of chronic liver disease, including decaffeinated, instant, and ground coffee. ...
- Oatmeal. ...
- Green tea. ...
- Garlic. ...
- Berries. ...
- Grapes. ...
- Grapefruit. ...
- Prickly pear.
In fact, some common herbs could cause toxic liver disease. Watch out for supplements that contain aloe vera, black cohosh, cascara, chaparral, comfrey, ephedra, or kava. Chemicals and solvents. Some workplace chemicals can harm your liver.
Is taking B12 bad for your liver? ›
The common forms of vitamin B include vitamin B1 (thiamine), B2 (riboflavin), B3 (niacin), B6 (pyridoxine) and B12 (cyanocobalamin). Except for niacin (when given in high doses), there is no evidence that the other B vitamins, in physiologic or even super-physiologic high doses cause liver injury or jaundice.
What is the best drink to flush your liver? ›
11 Drinks to Help Your Liver Detox
- Lemon Water.
- Ginger and Lemon Drink.
- Grapefruit Juice.
- Tumeric Tea.
- Green Tea.
- Chamomile Tea.
- Oat Tea.
- Jujube Fruit Juice.
In fact, some common herbs could cause toxic liver disease. Watch out for supplements that contain aloe vera, black cohosh, cascara, chaparral, comfrey, ephedra, or kava.
What spices are hard on the liver? ›
Hot spicy foods: Hot and spicy foods such as garlic, ginger, chili, coffee, pepper, ... are not good foods for people with fatty liver disease. If you deliberately eat it, it will make the condition worse and weakened because the liver cannot excrete fat.
Is Red Bull hard on your liver? ›
People are increasingly suffering from liver damage as a result of their addiction to energy drinks. One bottle of energy drinks contains the equivalent of 40 mg of niacin. If consuming excessive niacin will cause liver damage, with an LD50 limit niacin is 50 mg/kg BB.
Is red wine good for liver damage? ›
That said, the impact of red wine on liver health is complicated. Although it provides antioxidants and reduces oxidative stress, drinking can also increase uric acid and triglycerides, which damages the liver.
