RED CLOVER: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

Overview

Red clover (Trifolium pratense) is a flowering plant that grows 15-40 cm high. It's eaten as a legume and used in supplements marketed for female health.

Red clover contains chemicals called phytoestrogens that are similar to the hormone estrogen. It grows in many areas, including Europe, central Asia, and northern Africa.

People commonly use red clover for symptoms of menopause, weak and brittle bones, breast pain, male-pattern baldness, and many other conditions, but there is no good scientific evidence to support any of these uses.

Don't confuse red clover with sweet clover. They are different plants.

Uses & Effectiveness ?

We currently have no information for RED CLOVER overview.

Side Effects

When taken by mouth: Red clover is commonly consumed in foods. Red clover products contain chemicals called isoflavones. It is possibly safe to take red clover in doses that provide up to 80 mg of isoflavones daily for up to 2 years. It's usually well-tolerated, but might cause muscle aches, nausea, and vagin*l bleeding (spotting) in some people.

When applied to the skin: Red clover is possibly safe when used for up to 4 weeks.

Special Precautions and Warnings

When taken by mouth: Red clover is commonly consumed in foods. Red clover products contain chemicals called isoflavones. It is possibly safe to take red clover in doses that provide up to 80 mg of isoflavones daily for up to 2 years. It's usually well-tolerated, but might cause muscle aches, nausea, and vagin*l bleeding (spotting) in some people.

When applied to the skin: Red clover is possibly safe when used for up to 4 weeks. Pregnancy and breast-feeding: Red clover is commonly consumed in foods. But it's possibly unsafe when used in medicinal amounts. Red clover might act like estrogen, which could affect hormone balances during pregnancy or breast-feeding. Don't use it.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Red clover might act like estrogen. If you have any condition that might be made worse by estrogen, don't use red clover.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Estrogens interacts with RED CLOVER

    Large amounts of red clover might have some of the same effects as estrogen. Taking red clover along with estrogen might decrease the effects of estrogen.

  • Tamoxifen (Nolvadex) interacts with RED CLOVER

    Red clover might decrease the effects of tamoxifen. Do not take red clover if you are taking tamoxifen.

  • Methotrexate (Trexall, others) interacts with RED CLOVER

    Red clover might increase levels of methotrexate in the body. This might increase side effects from methotrexate such as vomiting and stomach pain.

    Minor Interaction

    Be watchful with this combination

  • Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with RED CLOVER

    Some medications are changed and broken down by the liver. Red clover might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with RED CLOVER

    Some medications are changed and broken down by the liver. Red clover might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with RED CLOVER

    Some medications are changed and broken down by the liver. Red clover might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with RED CLOVER

    Some medications are changed and broken down by the liver. Red clover might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with RED CLOVER

    Red clover might slow blood clotting. Taking red clover along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

  • Caffeine interacts with RED CLOVER

    Red clover contains the chemical genistein. Genistein might slow down how quickly the body gets rid of caffeine. But red clover doesn't seem to have enough of this ingredient to actually increase the effects of caffeine.

Dosing

Red clover has most often been used by adults in doses of 40-80 mg by mouth daily for up to one year. Keep in mind that doses vary depending on the specific product used. Speak with a healthcare provider to find out what product and dose might be best for a specific condition.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circ*mstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

RED CLOVER: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

FAQs

RED CLOVER: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews? ›

Special Precautions and Warnings

What are the side effects of taking red clover? ›

No serious side effects have been reported in people taking red clover for up to 1 year. General side effects may include headache, nausea, and rash. However, animals that graze on large amounts of red clover have become infertile.

What are the pros and cons of red clover? ›

Some research has found taking 40–80 mg of red clover daily may help reduce severe menopausal hot flashes. However, beyond this, little evidence supports using red clover to treat other health conditions. Though it has a good safety profile, some side effects include nausea, vomiting, headache, and vagin*l spotting.

Does red clover affect the kidneys? ›

Its anti-inflammatory properties may help reduce inflammation in the kidneys which can improve overall kidney function. Additionally, red clover tea's high antioxidant content may also help protect the kidneys from oxidative damage caused by free radicals.

What is red clover supplement used for? ›

Red clover contains substances called isoflavones—compounds that are structurally related/similar to estrogen. Red clover supplements have been promoted for menopause symptoms and osteoporosis. Historically, red clover was used for asthma, whooping cough, cancer, and gout.

Who Cannot take red clover? ›

Red clover might act like estrogen, which could affect hormone balances during pregnancy or breast-feeding. Don't use it. Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Red clover might act like estrogen.

Is red clover toxic to the liver? ›

Definition. Clover toxicity is caused by ingestion of alsike clover (Trifolium hybridum) or red clover (Trifolium pratense), resulting in signs of photosensitivity and liver failure.

How long does it take red clover to work? ›

How long does it take for Red Clover to work? This may depend on what you are taking Red Clover for. Some studies have had effective results in as little as 4 weeks, others went on for 12 weeks.

Is clover bad for cholesterol? ›

Studies in over 1,200 postmenopausal and perimenopausal women revealed that supplementing with red clover isoflavones lowered total cholesterol, LDL (bad) cholesterol, and triglyceride levels ( 18 ). Furthermore, over the study duration of 4 weeks to 18 months, HDL (good) cholesterol was significantly improved ( 18 ).

Is red clover an anti-inflammatory? ›

This may lessen the risk of cardiovascular disease, including coronary artery disease. Maintain your skin: Red clover contains antibacterial and anti-inflammatory properties.

What are the contraindications for red clover? ›

Red clover is contraindicated in patients with hormonal disorders, estrogen-dependent breast cancer (or risk of), and during pregnancy or lactation.

Does red clover affect blood pressure? ›

Conclusion: Isoflavone supplementation from red clover may favourably influence blood pressure and endothelial function in postmenopausal type 2 diabetic women.

Can red clover cause weight gain? ›

Does red clover cause weight loss? Since isoflavones can influence estradiol levels, they could cause weight gain.

Which is better, black cohosh or red clover? ›

Herbal remedies such as red clover contain plant hormones that can act in a similar way to oestrogen, while black cohosh is believed to balance oestrogen and progestogen levels. These may help with some menopause symptoms but this is not supported by scientific evidence.

Does red clover help with anxiety? ›

Red clover showed varying effects ranging from significant to non-significant on depression and anxiety.

Does red clover help balance hormones? ›

Red clover (Trifolium pratense L.) is a plant in the Fabaceae botanical family. It's used to make an herbal supplement that may have some immune-boosting and positive hormonal effects, especially for postmenopausal women.

Does red clover raise blood pressure? ›

Lowers blood pressure: Red clover has special benefits that include lowering inflammation across the body, especially in the cardiovascular system. According to numerous studies, red clover tea can greatly decrease the tension in the arteries and blood vessels, which helps lower blood pressure.

How long does it take for red clover to work? ›

How long does it take for Red Clover to work? This may depend on what you are taking Red Clover for. Some studies have had effective results in as little as 4 weeks, others went on for 12 weeks.

Does red clover increase testosterone? ›

Consumption of red clover by menopausal women could increase the level of luteinizing hormone, decrease the level of sex-hormone-binding globulin, increase the level of testosterone and also increase the level of blood estradiol; although it has no effect on the thickness of endometrium, it could decrease the severity ...

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